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1

Effective use of preparative chiral HPLC in a preclinical drug synthesis

Todd D. Nelson, Christopher J. Welch, Jonathan D. Rosen, Jacqueline H. Smitrovich, Mark A. Huffman, James M. McNamara, David J. Mathre

Journal:

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

2

Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to Mitsunobu conditions

Thompson, Andrew S., Humphrey, Guy R., DeMarco, Anthony M., Mathre, David J., Grabowski, Edward J. J.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 360 KB

english, 1993

3

Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725

Song, Zhiguo, DeMarco, Anthony, Zhao, Mangzhu, Corley, Edward G., Thompson, Andrew S., McNamara, James, Li, Yulan, Rieger, Dale, Sohar, Paul, Mathre, David J., Tschaen, David M., Reamer, Robert A., Hu

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 275 KB

english, 1999

4

A Highly Efficient Synthesis of Fibrinogen Receptor Antagonist L-734,217 via a Novel Chemoselective Silyl-Mediated Conjugate Addition of δ-Lactams to 4-Vinylpyridine

Chung, John Y. L., Hughes, David L., Zhao, Dalian, Song, Zhiguo, Mathre, David J., Ho, Guo-Jie, McNamara, James M., Douglas, Alan W., Reamer, R. A., Tsay, Fuh-Rong, Varsolona, Richard, McCauley, James

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 317 KB

english, 1996

5

Improved Method for Rapid Evaluation of Chiral Stationary Phase Libraries †

Welch, Christopher J., Pollard, Scott D., Mathre, David J., Reider, Paul J.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

6

Microplate evaluation of process adsorbents

Christopher J. Welch, Mohamed Shaimi, Mirlinda Biba, Jennifer R. Chilenski, Ronald H. Szumigala Jr., Ulf Dolling, David J. Mathre, Paul J. Reider

Journal:

Journal of Separation Science

Year:

2002

Language:

english

File:

PDF, 1.06 MB

english, 2002

7

ChemInform Abstract: Asymmetric Aza-Diels—Alder Reactions of Indole 2-Carboxaldehydes.

Jeffrey T. Kuethe, Ian W. Davies, Peter G. Dormer, Robert A. Reamer, David J. Mathre, Paul J. Reider

Journal:

Year:

2002

File:

PDF, 31 KB

2002

8

Nucleophilic Displacement at Benzhydryl Centers: Asymmetric Synthesis of 1,1,Diarylalkyl Derivatives.

Yuri Bolshan, Cheng-yi Chen, Jennifer R. Chilenski, Francis Gosselin, David J. Mathre, Paul D. O'Shea, Amelie Roy, Richard D. Tillyer

Journal:

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

9

New Insights into the Mechanism of Molybdenum-Catalyzed Asymmetric Alkylation

Shane W. Krska, David L. Hughes, Robert A. Reamer, David J. Mathre, Michael Palucki, Nobuyoshi Yasuda, Yongkui Sun, Barry M. Trost

Journal:

Year:

2004

File:

PDF, 54 KB

2004

10

Highly Selective Synthesis of 2-Substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic Acid Derivatives Using a Novel Protected Dihydroxyfumarate.

Spencer D. Dreher, Norihiro Ikemoto, Venita Gresham, Jinchu Liu, Peter G. Dormer, Jaume Balsells, David Mathre, Thomas J. Novak, Joseph D. III Armstrong

Journal:

Year:

2004

File:

PDF, 18 KB

2004

11

Mechanistic Studies of Molybdenum-Catalyzed Asymmetric Alkylation

David L. Hughes, Shane W. Krska, Robert A. Reamer, David J. Mathre, Yongkui Sun

Journal:

Year:

2005

File:

PDF, 8 KB

2005

12

Studies on the racemization of a stereolabile 5-aryl-thiazolidinedione

Christopher J. Welch, Michael H. Kress, Maria Beconi, David J. Mathre

Journal:

Year:

2003

Language:

english

File:

PDF, 117 KB

english, 2003

13

Discovery of a stable molecular complex of an API with HCl: A long journey to a conventional salt

Andrey Peresypkin, Narayan Variankaval, Russell Ferlita, Robert Wenslow, Jacqueline Smitrovich, Karen Thompson, Jerry Murry, Louis Crocker, David Mathre, Jian Wang, Paul Harmon, Martha Ellison, Sherry

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 250 KB

english, 2008

14

Direct isomeric separation of a 3-hydroxyproline-containing prodrug, L-693 989, by high-performance liquid chromatography with a porous graphitic carbon column

Carrie Bell, Eric W. Tsai, Dominic P. Ip, David J. Mathre

Journal:

Journal of Chromatography A

Year:

1994

Language:

english

File:

PDF, 467 KB

english, 1994

15

Crystal structure and surface properties of an investigational drug—A case study

Y.-H. Kiang, H.Galen Shi, David J. Mathre, Wei Xu, Dina Zhang, Santipharp Panmai

Journal:

International Journal of Pharmaceutics

Year:

2004

Language:

english

File:

PDF, 328 KB

english, 2004

16

Scalable, efficient process for the synthesis of (R)-3,5-bistrifluoromethylphenyl ethanol via catalytic asymmetric transfer hydrogenation and isolation as a DABCO inclusion complex

Karl B. Hansen, Jennifer R. Chilenski, Richard Desmond, Paul N. Devine, Edward J.J. Grabowski, Richard Heid, Michele Kubryk, David J. Mathre, Richard Varsolona

Journal:

Tetrahedron: Asymmetry

Year:

2003

Language:

english

File:

PDF, 223 KB

english, 2003

17

Highly selective synthesis of 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives using a novel protected dihydroxyfumarate

Spencer D. Dreher, Norihiro Ikemoto, Venita Gresham, Jinchu Liu, Peter G. Dormer, Jaume Balsells, David Mathre, Thomas J. Novak, Joseph D. Armstrong III

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 283 KB

english, 2004

18

Asymmetric aza-Diels–Alder reactions of indole 2-carboxaldehydes

Jeffrey T Kuethe, Ian W Davies, Peter G Dormer, Robert A Reamer, David J Mathre, Paul J Reider

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 111 KB

english, 2002

19

Practical chemoenzymatic synthesis of a 3-pyridylethanolamino β3 adrenergic receptor agonist

John Y.L Chung, Guo-Jie Ho, Michel Chartrain, Chris Roberge, Dalian Zhao, John Leazer, Roger Farr, Michael Robbins, Kateeta Emerson, David J Mathre, James M McNamara, David L Hughes, Edward J.J Grabow

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 293 KB

english, 1999

20

Dissolving metal reductions with sodium potassium alloy in the presence of 18-crown-6

David J. Mathre, Wayne C. Guida

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 291 KB

english, 1980

21

A practical enantioselective synthesis of .alpha.,.alpha.-diaryl-2-pyrrolidinemethanol. Preparation and chemistry of the corresponding oxazaborolidines

Mathre, David J., Jones, Todd K., Xavier, Lyndon C., Blacklock, Thomas J., Reamer, Robert A., Mohan, Julie J., Jones, E. Tracy Turner, Hoogsteen, Karst, Baum, Mary W., Grabowski, E. J. J.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 2.02 MB

english, 1991

22

Asymmetric bioreduction of a β-ketoester to (R)-β-hydroxyester by the fungus Mortierella alpina MF 5534

Michel Chartrain, Joseph Armstrong, Lorraine Katz, Jennifer Keller, David Mathre, Randolph Greasham

Journal:

Journal of Fermentation and Bioengineering

Year:

1995

Language:

english

File:

PDF, 466 KB

english, 1995

23

Lipid nanoparticle purification by Spin Centrifugation–Dialysis (SCD): A facile and high-throughput approach for small scale preparation of siRNA–lipid complexes

Radu Mihaila, Silvia Chang, Alan T. Wei, Zhi Y. Hu, Dipali Ruhela, Timothy R. Shadel, Sven Duenwald, Elmer Payson, James J. Cunningham, Nelly Kuklin, David J. Mathre

Journal:

International Journal of Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 442 KB

english, 2011

24

Origins of the enantioselectivity observed in oxazaborolidine-catalyzed reductions of ketones

Jones, Deborah K., Liotta, Dennis C., Shinkai, Ichiro, Mathre, David J.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 267 KB

english, 1993

25

Phase-transfer alkylation of heterocycles in the presence of 18-crown-6 and potassium tert-butoxide

Guida, Wayne C., Mathre, David J.

Journal:

Journal of Organic Chemistry

Year:

1980

Language:

english

File:

PDF, 671 KB

english, 1980

26

Asymmetric bioreduction of cyclohexylphenyl ketone to its corresponding alcohol (+) cyclohexylphenyl alcohol by the yeast Candida magnoliae MY 1785

Michel Chartrain, David Mathre, Robert A. Reamer, Shashikant Patel, Ichiro Shinkai, Randolph Greasham

Journal:

Journal of Fermentation and Bioengineering

Year:

1997

Language:

english

File:

PDF, 286 KB

english, 1997

27

Adsorbent Screening for Metal Impurity Removal in Pharmaceutical Process Research

Welch, Christopher J., Albaneze-Walker, Jennifer, Leonard, William R., Biba, Mirlinda, DaSilva, Jimmy, Henderson, Derek, Laing, Brian, Mathre, David J., Spencer, Sandra, Bu, Xiaodong, Wang, Tiebang

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 607 KB

english, 2005

28

An asymmetric synthesis of MK-0417. Observations on oxazaborolidine-catalyzed reductions

Jones, Todd K., Mohan, Julie J., Xavier, Lyndon C., Blacklock, Thomas J., Mathre, David J., Sohar, Paul, Jones, E. Tracy Turner, Reamer, Robert A., Roberts, F. E., Grabowski, E. J. J.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 1.05 MB

english, 1991

29

Lithium-Initiated Imide Formation. A Simple Method for N-Acylation of 2-Oxazolidinones and Bornane-2,10-Sultam

Ho, Guo-Jie, Mathre, David J.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 340 KB

english, 1995

30

Nucleophilic Displacement at Benzhydryl Centers: Asymmetric Synthesis of 1,1-Diarylalkyl Derivatives

Bolshan, Yuri, Chen, Cheng-yi, Chilenski, Jennifer R., Gosselin, Francis, Mathre, David J., O'Shea, Paul D., Roy, Amélie, Tillyer, Richard D.

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 71 KB

english, 2004

31

2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ): A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J., Mills, Sander G., MacCoss, Malcolm, Shah, Shrenik K., Qi, Hongbo, Mathre, David J., Cascieri, Margaret A., Sadowski, Sharon, Strader, Catherine D., MacIntyre, D. Euan, Metzger, Josep

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 140 KB

english, 1996

32

Synthetic studies in the lysocellin family of polyether antibiotics. The total synthesis of ferensimycin B

Evans, David A., Polniaszek, Richard P., DeVries, Keith M., Guinn, Denise E., Mathre, David J.

Journal:

Journal of the American Chemical Society

Year:

1991

Language:

english

File:

PDF, 3.74 MB

english, 1991

33

Encyclopedia of Reagents for Organic Synthesis || Tetrahydro-1-methyl-3,3-diphenyl-1 H , 3 H -pyrrolo[1,2- c ][1,3,2]oxazaborole

Mathre, David J.

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

34

Asymmetric synthesis of the enkephalinase inhibitor thiorphan

Evans, David A., Mathre, David J., Scott, William L.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 915 KB

english, 1985

35

Chromatography as an Enabling Technology in Pharmaceutical Process Development: Expedited Multikilogram Preparation of a Candidate HIV Protease Inhibitor

Welch, Christopher J., Fleitz, Fred, Antia, Firoz, Yehl, Pete, Waters, Robert, Ikemoto, Norihiro, Armstrong, Joseph D., Mathre, David J.

Journal:

Organic Process Research & Development

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

36

Practical enantioselective synthesis of a homotyrosine derivative and (R,R)-4-propyl-9-hydroxynaphthoxazine, a potent dopamine agonist

Melillo, David G., Larsen, Robert D., Mathre, David J., Shukis, William F., Wood, Alfred W., Colleluori, Joseph R.

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 1.13 MB

english, 1987

37

Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate−ZnCl 2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor

Chung, John Y. L., Cvetovich, Raymond J., Tsay, Fuh-Rong, Dormer, Peter G., DiMichele, Lisa, Mathre, David J., Chilenski, Jennifer R., Mao, Bing, Wenslow, Robert

Journal:

Journal of Organic Chemistry

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

38

A practical process for the preparation of tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole-borane. A highly enantioselective stoichiometric and catalytic reducing agent

Mathre, David J., Thompson, Andrew S., Douglas, Alan W., Hoogsteen, Karst, Carroll, James D., Corley, Edward G., Grabowski, Edward J. J.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 1.15 MB

english, 1993

39

The Unusual Role of CO Transfer in Molybdenum-Catalyzed Asymmetric Alkylations

Krska, Shane W., Hughes, David L., Reamer, Robert A., Mathre, David J., Sun, Yongkui, Trost, Barry M.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

40

Carbodiimide-Mediated Amide Formation in a Two-Phase System. A High-Yield and Low-Racemization Procedure for Peptide Synthesis

Ho, Guo-Jie, Emerson, Khateeta M., Mathre, David J., Shuman, Richard F., Grabowski, Edward J. J.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 316 KB

english, 1995

41

Use of Chiral HPLC-MS for Rapid Evaluation of the Yeast-Mediated Enantioselective Bioreduction of a Diaryl Ketone

Welch, Christopher J., Grau, Brendan, Moore, Jeff, Mathre, David J.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

42

Encyclopedia of Reagents for Organic Synthesis || 2-Amino-3-methyl-1,1-diphenyl-1-butanol

Mathre, David J.

Year:

2001

Language:

english

File:

PDF, 401 KB

english, 2001

43

Encyclopedia of Reagents for Organic Synthesis || α,α-Diphenyl-2-pyrrolidinemethanol

Mathre, David J.

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

44

Encyclopedia of Reagents for Organic Synthesis (Paquette/e-EROS) || α,α-Diphenyl-2-pyrrolidinemethanol

Mathre, David J.

Year:

1995

Language:

english

File:

PDF, 234 KB

english, 1995

45

Encyclopedia of Reagents for Organic Synthesis || 2-Amino-3-methyl-1,1-diphenyl-1-butanol

Mathre, David J.

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001